HFA 24: Differential Effects of Inter-Atrial Shunt Treatment in HF Patients with Reduced Vs Preserved Ejection Fraction: RELIEVE-HF

Published: 17 May 2024

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HFA 24 - We are joined onsite by Dr Michael Zile (Medical University of South Carolina, US) to discuss the outcomes of the RELIEVE-HF trial.

RELIEVE-HF is designed to evaluate the safety and effectiveness of the V-Wave interatrial shunt system in patients with heart failure. 605 participants with New York Heart Association (NYHA) functional class II, class III or class IV heart failure, who had been treated with guideline-directed drug and device therapies were enrolled in the trial, and randomized 1:1 to recieve either the interatrial shunt, or were part of the control arm. In this interview, Dr Zile outlines the differencial effects of inter-atrial shunt treatment on cardiac structure and function in patients with reduced vs preserved ejection fraction.

Findings showed that in HFrEF, interatrial shunt treatment was tolerated without increased right ventricular preload or afterload. In HFpEF, left and right heart were non-compliant at baseline, and remained non-compliant after interatrial shunt treatment. These findings suggest a mechanistic basis for the differences in clinical outcomes seen between both arms.

Interview Questions:

  1. What is the reasoning behind this study?
  2. Could you tell us more about the V-Wave shunt system?
  3. What was the patient population and study design?
  4. What are the key findings in regard to treament effects in patients with HFpEF and HFrEF?
  5. What are your take-home messages?
  6. Where are the knowledge gaps, and what further study is needed?

Recorded onsite at HFA 2024, Lisbon.

Support: This is an independent interview conducted by Radcliffe Cardiology.

Editor: Jordan Rance
Video Specialists: Tom Green, Oliver Miles
Interviewer: Jonathan McKenna


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