ESC-HFA 2023: Late-Breaking Science Video Collection

Published: 23 May 2023

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Get the most out of the new data from, Late-breaker host, Dr Harriette Van Spall and Dr James Januzzi wrap up of the most impactful trials and studies presented at Heart Failure 2023.

Delve into in-depth and critical discussions with Dr Van Spall in our thought-provoking Late-breaker Discussion series.

For concise and practical take-home messages for practice and cardiovascular research watch our 5-minute Expert Interviews conducted with investigators.

Watch our Behind the Heart Series to hear more from the personal perspectives of the investigators behind the top trials of HFA 2023. 

About the episode

Dr Ross Campbell joins us onsite to discuss the findings of the DAPA-RESIST Trial, which aimed to assess the affect of dapagliflozin as compared to metolazone in heart failure patients with diuretic resistance. (NCT04860011)

In this phase 3 trial, investigators studied whether SGLT2i led to greater diuresis in this patient group, as to the standard practice use of metolazone in addition to furosemide. 61 patients were enrolled into the study.

Findings suggest that both dapagliflozin and metolazone were well-tolerated and effective at treating diuretic resistance in this cohort of patients. 

Interview Questions:

  1. What is the rationale for this pragmatic trial?
  2. What was study design, patient population and outcome measures?
  3. What is the key data presented at HFA 23?
  4. What are the take-home messages of practicing clinicians?
  5. How do these findings complement the results of EMPEROR-Preserved and DELIVER?
  6. What are the next steps?

Faculty Biographies

Ross Campbell

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