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Author(s): William T Abraham , Adam Pleister , Robin Germany Added: 3 years ago
Central sleep apnoea (CSA) occurs in approximately one-third of patients with HF and is associated with a significant increase in morbidity and mortality compared to HF patients without CSA.1–3 CSA results in intermittent hypoxia and activation of the renin–angiotensin system, which contributes to worsening HF.4 Symptoms such as fatigue and difficulty concentrating often overlap with the effects… View more

Heart Failure

Prevention & Chronic Conditions
Author(s): Ali Valika , Maria Rosa Costanzo Added: 3 years ago
Sleep-disordered breathing (SDB) is common in heart failure (HF) patients and is associated with increased morbidity and mortality. Abnormal sleep patterns are often characterised by cycles of significant pauses in breathing and partial neurological arousals that lead to maladaptive neurohormonal activation. SDB is broadly classified into two types: obstructive sleep apnea (OSA) and central sleep… View more

Heart Failure
Author(s): Ali Vazir , Kostantinos Bronis , Simon G Pearse Added: 3 years ago
Central sleep apnoea (CSA) is characterised by cycles of apnoea, hypopnoea and hyperpnoea during sleep due to abnormalities in the regulation of breathing within the respiratory centre in the brainstem. CSA, defined as an apnoea–hypopnoea index (AHI) of ≥15 events/h, is common in patients with heart failure (HF), with a prevalence of 20–45 %.1, 2 Its presence is reported to be a marker of… View more

Heart Failure
William T Abraham
Research Area(s) / Expertise:

Heart Failure

 Job title: Professor of Internal Medicine and Chief of the Division of Cardiovascular Medicine
Prof Abraham is a College of Medicine Distinguished Professor. He has been recognized as one of the “Best Doctors in America” for 18 consecutive years.His research has led to the approval/adoption of new heart failure therapies, including beta-blockers, natriuretic peptides, cardiac resynchronization therapy, ultrafiltration, implantable hemodynamic monitoring, transvenous phrenic nerve… View more
Author(s): Martin R Cowie , Holger Woehrle , Olaf Oldenburg , et al Added: 3 years ago
Heart Failure In developed countries, approximately 1–2 % of the adult population has heart failure (HF), and the prevalence of this cardiovascular disease increases with age.1,2 HF can occur in the presence or absence of reduced left ventricular ejection fraction (LVEF), known as HF with reduced ejection fraction (HF-rEF) and HF with preserved ejection fraction (HF-pEF), respectively. The most… View more

Standards & Guidelines

Heart Failure
ESC 22: ADVENT-HF: Adaptive Servo Ventilation in Pts with HF ＆ Sleep Apnea
Author(s): Douglas Bradley Added: 1 year ago
ESC 22 - In this short interview filmed onsite at ESC Congress 2022, Dr Douglas Bradley (University of Toronto, Toronto, CA) discusses the findings of the ADVENT-HF Trial (NCT01128816). ADVENT-HF was designed to determine if a respiratory device, Adaptive Servo Ventilation can reduce the risk of cardiovascular hospitalisations and death in patients with heart failure and sleep apnoea. 732… View more

Heart Failure

Prevention & Chronic Conditions
Foreword

Article

Author(s): Andrew JS Coats , Giuseppe Rosano Added: 3 years ago
We have great pleasure in introducing the latest issue of Cardiac Failure Review. We have been impressed with the extra information that has flooded in concerning the new classification of heart failure (including for the first time heart failure with mid-range ejection fraction [HFmrEF]) popularised by the influential 2016 European Society of Cardiology and Heart Failure Association Guidelines.1… View more

Heart Failure
Author(s): Nadja Scherbakov , Wolfram Doehner Added: 3 years ago
Heart failure (HF) is a complex clinical syndrome with more than 15 million diagnosed cases worldwide.1,2 Characterised by structural or functional impairment of ventricular filling or ejection fraction (EF)3, HF is frequently accompanied by multiple comorbidities. Brain disorders, including stroke, mental disturbances and cognitive impairment are distinct from the comorbidities traditionally… View more

Heart Failure
Author(s): Frans H Rutten , Joe Gallagher Added: 3 years ago
“I cannot keep pace with my husband. Is it simply ageing, overweight and my sedentary lifestyle?” This is a common encounter in primary care, bearing in mind that around 16 % of older community-dwelling people experience at least grade 3 shortness of breath according to the Medical Research Council questionnaire (“walk slower than people of the same age because of breathlessness or have to stop… View more

Standards & Guidelines

Heart Failure
Author(s): Justien Cornelis , Jonathan Myers , Hein Heidbuchel , et al Added: 3 years ago
A hallmark symptom of chronic heart failure (CHF) is exercise intolerance associated with early fatigue and/or dyspnoea with a minimal degree of exertion. It is also associated with a decline in capacity to perform activities of daily living and a diminished quality of life (QoL). Both patients with heart failure with reduced left ventricular ejection fraction (HFrEF) and those with heart failure… View more

Heart Failure