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Author(s): Mark Sweeney , Angela Yiu , Alexander Lyon Added: 3 years ago
Cancer and the anti-cancer treatments prescribed by oncologists have long been known to have significant effects on muscle, causing a catabolic muscle wasting state and resulting in widespread and progressive atrophy of most muscle groups.1 This process contributes significantly to the cancer cachexia seen in up to 80% of all patients with cancer, resulting in progressive weight loss, loss of… View more

Heart Failure
Alexander Lyon
Research Area(s) / Expertise: Job title: Consultant Cardiologist
Dr Alexander Lyon is a leading London-based consultant cardiologist, specialising in the field of heart failure, cardiomyopathy, cardio-oncology and takotsubo syndrome. He is highly experienced, and is well-versed in all aspects of cardiology. Along with his private clinics at Royal Brompton Hospital and in central London, he is also senior lecturer for the National Heart and Lung Institute at… View more
Author(s): Giuseppe Rosano , Cristiana Vitale Added: 3 years ago
Heart failure (HF) affects 1–2% of the population in developed countries and absorbs a significant amount of human and economic resources.1–3 It is a complex syndrome, characterised by a spectrum of symptoms and signs ranging from minimal loss of normal functional capacity to more severe symptoms refractory to medical therapy. It may be associated with different aetiologies and varying degrees of… View more

Heart Failure
Imaging of Congestion in Heart Failure
Author(s): Fraser J Graham , Antonio Iaconelli , Piotr Sonecki , et al Added: 10 months ago

Imaging & Diagnostics

Heart Failure
Treating Acute Heart Failure with Chronic Obstructive Pulmonary Disease
Author(s): Jelena Celutkiene , Mindaugas Balčiūnas , Denis Kablučko , et al Added: 3 years ago
Heart failure (HF) and chronic obstructive pulmonary disease (COPD) comorbidity poses substantial diagnostic and therapeutic challenges in acute care settings. Outcomes of this comorbidity are worse than in either disease alone.1,2 A hospital diagnosis of COPD is an independent predictor of all-cause and non-cardiovascular mortality in HF patients,3–5 associated with decrease in use of evidence… View more

Vascular Disease and Surgery

Heart Failure
Author(s): Yury Lopatin Added: 3 years ago
Heart failure is currently one of the leading causes of death and disability worldwide, which makes it a major public health problem.1,2 Traditionally, heart failure is considered a complex syndrome with several features, including abnormal myocardial function and excessive, continuous neurohumoral activation. In this context, the current optimal pharmacological treatment of heart failure focuses… View more

Heart Failure
Left Ventricular Assist Device Support Complicates the Exercise Physiology of Oxygen Transport and Uptake in Heart Failure
Author(s): Erik H Van Iterson Added: 3 years ago
The maximal exercise oxygen uptake (VO2 max) response physiologically reflects the clinical status of patients with low-output left heart failure (HF). The failure of VO2 max to rise above 12 ml/kg/min is a hallmark of deteriorated clinical status, impaired oxidative metabolic capacity and indicates advanced medical therapy is required to prolong life.1,2 The continuous-flow left ventricular… View more

Heart Failure
Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use
Author(s): Zoltán Papp , Piergiuseppe Agostoni , Julian Alvarez , et al Added: 3 years ago
Origins of a Unique Cardiovascular Agent Before the 1980s, therapy to enhance cardiac contractility in heart failure (HF) substantially meant oral digitalis glycosides, supplemented by beta-adrenergic agonists such as dopamine or dobutamine (introduced in the middle of the 1970s) in acute situations.1 It was therefore a matter of some note when the US Food and Drug Administration approved a new… View more

Heart Failure
Author(s): Izabella Uchmanowicz , Anna Chudiak , Beata Jankowska-Polańska , et al Added: 3 years ago
Hypertension is considered the most common disorder in the general population. It is both a health and a financial problem worldwide. The Writing Group of the American Society of Hypertension defines hypertension as a cardiovascular syndrome resulting from a number of interconnected factors.1 Therefore, a comprehensive evaluation is required, involving both the cardiovascular system and other… View more

Heart Failure

Prevention & Chronic Conditions
Cardiac Toxicity of Cancer Chemotherapy
Author(s): Aarti Asnani Start date: Aug 08, 2017

Heart Failure