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Author(s): Ovidiu Chioncel , Sean P Collins , Andrew P Ambrosy , et al Added: 3 years ago
Acute heart failure (AHF) is a heterogeneous clinical syndrome including diverse phenotypes sharing similar presenting signs and symptoms.1 The diversity of aetiologies and precipitants of HF and their specific pathophysiologic mechanisms, may result in distinct clinical profiles requiring specific treatment approaches. Pulmonary oedema (PO) is a common manifestation of AHF associated with a… View more

Heart Failure
Pirfenidone for Lung and Cardiac Disorders
Author(s): Alberto Aimo , Giosafat Spitaleri , Dario Nieri , et al Added: 2 years ago

Heart Failure
Left Ventricular Assist Device Support Complicates the Exercise Physiology of Oxygen Transport and Uptake in Heart Failure
Author(s): Erik H Van Iterson Added: 3 years ago
The maximal exercise oxygen uptake (VO2 max) response physiologically reflects the clinical status of patients with low-output left heart failure (HF). The failure of VO2 max to rise above 12 ml/kg/min is a hallmark of deteriorated clinical status, impaired oxidative metabolic capacity and indicates advanced medical therapy is required to prolong life.1,2 The continuous-flow left ventricular… View more

Heart Failure
Treating Acute Heart Failure with Chronic Obstructive Pulmonary Disease
Author(s): Jelena Celutkiene , Mindaugas Balčiūnas , Denis Kablučko , et al Added: 3 years ago
Heart failure (HF) and chronic obstructive pulmonary disease (COPD) comorbidity poses substantial diagnostic and therapeutic challenges in acute care settings. Outcomes of this comorbidity are worse than in either disease alone.1,2 A hospital diagnosis of COPD is an independent predictor of all-cause and non-cardiovascular mortality in HF patients,3–5 associated with decrease in use of evidence… View more

Vascular Disease and Surgery

Heart Failure
Author(s): Katerina Fountoulaki , Nikolaos Dagres , Efstathios K Iliodromitis Added: 3 years ago
Heart failure (HF) is a feared endpoint for most cardiovascular diseases and is a major cause of morbidity and mortality. The worldwide prevalence of HF is between 2 and 3 % and rises sharply at around 75 years of age, so that the prevalence in 70- to 80-year-old people is between 10–20 %. With a 50 % 5-year survival rate, HF is predicted to be the leading cause of all morbidity by 2020.1,2… View more

Heart Failure
Author(s): Christopher J Allen , Kaushik Guha , Rakesh Sharma Added: 3 years ago
Acute heart failure (AHF) is a leading cause of hospitalisation in developed nations, responsible for 67,000 admissions a year in the UK alone, an incidence which is set to increase with an ageing population.1 The prognosis remains poor: in-hospital mortality ranges from 4–11 % and in those patients surviving to discharge 50 % will be re-admitted and one-third will die within 12 months.2–6 These… View more

Imaging & Diagnostics

Heart Failure
Thomas Gilpin
Job title: Interventional Cardiology Research Fellow
Personal History Dr Thomas Gilpin is a British cardiologist. He is an Interventional Cardiology Research Fellow at the University Hospital Southampton NHS Foundation Trust. Academic History From 2008 to 2013, he attended Cardiff University where he studied Medicine.1 In 2020, Dr Gilpin started work on a PhD in Medicine, Human Development and Health at the University of Southampton… View more
Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
Author(s): Piergiuseppe Agostoni , Dimitrios T Farmakis , Jose M García-Pinilla , et al Added: 3 years ago
The use of IV vasoactive drugs, diuretics, vasodilators and inotropes for correcting haemodynamic dysfunction in patients with decompensated heart failure has been described over many decades.1 However, data on their effects on prognosis do not offer a convincing picture of clinical benefit.2 This is particularly true regarding IV inotropes. Clinical data collected on the effects of cardiac… View more

Heart Failure
SGLT2 Inhibitors in HFpEF
Author(s): Brent Deschaine , Sahil Verma , Hussein Rayatzadeh Added: 1 year ago

Heart Failure
Ulrich Schotten
Job title: Full professor and Chairman of the Department of Physiology
Personal History Professor Ulrich Schotten is based in the Netherlands, where he works at Maastricht University. Academic History Professor Ulrich Schotten studied medicine at the universities of Aachen, Germany, Glasgow, Scotland and Valletta, Malta. At Aachen University, he defended his thesis in 1996 on the topic of the effects of volatile anaesthetics on βadrenergic signalling in… View more