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Author(s):
Julio A Chirinos
,
Nancy Sweitzer
Added:
3 years ago
Detailed phenotyping of ventricular–arterial coupling (VAC) and systemic arterial haemodynamics provide important insights into the pathophysiology of left ventricular (LV) energetics, remodelling and fibrosis, and systolic and diastolic dysfunction in various disease states including heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF).1…
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Author(s):
Mattia Arrigo
,
Petra Nijst
,
Alain Rudiger
Added:
3 years ago
Heart failure is a clinical syndrome induced by cardiac abnormalities resulting in reduced cardiac output and/or elevated intra-cardiac end-diastolic pressures and causing symptoms that are often accompanied by typical physical signs.1 Demographic changes, improved treatment of several acute cardiac disorders, such myocardial infarction, arrhythmia and congenital heart disease, and increased long…
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Author(s):
Sriram D Rao
,
Srinath Adusumalli
,
Jeremy A Mazurek
Added:
3 years ago
Heart failure (HF) remains one of the most common medical conditions worldwide, placing a continuously growing burden on healthcare providers. Within the HF population itself, the subset of patients who develop pulmonary hypertension (PH-LHD) has been identified as having a significantly higher morbidity and mortality.1 There are limited therapeutic options for PH-LHD and it often complicates the…
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Author(s):
Mattia Arrigo
,
Lars Christian Huber
,
Stephan Winnik
,
et al
Added:
3 years ago
In 1616, Sir William Harvey was the first person to describe the importance of right ventricular function.1 However, the right ventricle (RV) has received little attention in the past, with cardiology dealing mostly with the diseases of the left ventricle (LV) and their potential treatment. Since the early 1950s, however, the prognostic significance of RV function has been recognised in several…
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Author(s):
Conor P Kerley
Added:
3 years ago
Heart failure (HF) is a major cause of hospitalisation, morbidity and mortality. Nutritional factors are major contributors to HF precursors, including hypertension, obesity, dyslipidaemia, insulin resistance/diabetes and systemic inflammation. Multiple landmark trials, including Dietary Approaches to Stop Hypertension (DASH)1 and Prevención con Dieta Mediterránea (PREDIMED),2 have documented the…
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Author(s):
Mauro Gori
,
Attilio Iacovoni
,
Michele Senni
Added:
3 years ago
Despite the burden of heart failure (HF) with preserved ejection fraction (HFpEF),1 its pathophysiological mechanisms remain controversial and are likely to be multifactorial.2,3,4 The lack of a comprehensive paradigm applicable to all patients suggests that haemodynamic derangements responsible for this disorder may be quite heterogeneous. As recently highlighted, haemodynamic features of HFpEF…
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Author(s):
Erik H Van Iterson
Added:
3 years ago
The maximal exercise oxygen uptake (VO2 max) response physiologically reflects the clinical status of patients with low-output left heart failure (HF). The failure of VO2 max to rise above 12 ml/kg/min is a hallmark of deteriorated clinical status, impaired oxidative metabolic capacity and indicates advanced medical therapy is required to prolong life.1,2 The continuous-flow left ventricular…
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Author(s):
Katerina Fountoulaki
,
Nikolaos Dagres
,
Efstathios K Iliodromitis
Added:
3 years ago
Heart failure (HF) is a feared endpoint for most cardiovascular diseases and is a major cause of morbidity and mortality. The worldwide prevalence of HF is between 2 and 3 % and rises sharply at around 75 years of age, so that the prevalence in 70- to 80-year-old people is between 10–20 %. With a 50 % 5-year survival rate, HF is predicted to be the leading cause of all morbidity by 2020.1,2…
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Author(s):
Erez Marcusohn
,
Ofer Kobo
,
Maria Postnikov
,
et al
Added:
2 years ago
Author(s):
Firas Zahr
Added:
3 weeks ago
THT 24 - We are joined by Dr Firas Zahr (OHSU Knight Cardiovascular Institute Cardiology Clinic, US) to discuss the findings from the ALT FLOW Early Feasibility study (NCT03523416).The ALT FLOW Early Feasibility study aims to assess the initial clinical safety, functionality and effectiveness of a transcatheter atrial shunt system created by Edwards. 75 patients with symptomatic heart failure…
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