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Author(s): Federica Jiritano , Valeria Lo Coco , Matteo Matteucci , et al Added: 3 years ago
Cardiogenic shock (CS) is a circulatory failure as a consequence of left, right or biventricular dysfunction.1 It leads to critical end-organ hypoperfusion due to primary cardiac dysfunction.1 Therefore, CS is not only a cardiac disease but also a multiorgan dysfunction syndrome involving the entire circulatory system, often complicated by a systemic inflammatory response syndrome.2 The goals of… View more
Author(s): Sajad Shehab , Christopher S Hayward Added: 3 years ago
The use of left ventricular assist devices (LVADs) in patients with advanced heart failure is well established; they make up 90% of all implanted continuous flow ventricular assist devices (VADs).1 In advanced heart failure, they are superior to medical therapy alone,1 with improvements demonstrated in survival, quality of life and functional status in carefully selected patients.2,3 Although… View more
Author(s): Syed Yaseen Naqvi , Ibrahim G Salama , Ayhan Yoruk , et al Added: 3 years ago
Heart failure is a progressive and fatal disease that affects more than 23 million people worldwide, and will affect more than 8 million people in the USA by 2030.1,2 Despite major advancements in medical and device treatments for heart failure in recent decades, the incidence of heart failure continues to rise. This epidemic has a major impact on patient quality of life, while imposing heavy… View more
Author(s): Mattia Arrigo , Lars Christian Huber , Stephan Winnik , et al Added: 3 years ago
In 1616, Sir William Harvey was the first person to describe the importance of right ventricular function.1 However, the right ventricle (RV) has received little attention in the past, with cardiology dealing mostly with the diseases of the left ventricle (LV) and their potential treatment. Since the early 1950s, however, the prognostic significance of RV function has been recognised in several… View more
Author(s): Edo Y Birati , Mariell Jessup Added: 3 years ago
Heart failure (HF) is a leading cause of morbidity and mortality worldwide, affecting 1–2% of the adult population in western countries with incidence of 5–10 per 1000 persons per year.1,2 It is estimated that the prevalence of HF will continue to increase as the population ages and, according to the American Heart Association (AHA), by the year 2030 the prevalence of HF in the US alone will rise… View more
Author(s): Mark IM Noble Added: 3 years ago
The simplicity of the concept of contractility is illustrated in Figure 1, which is the case for a strip of muscle connected to a force transducer. If one records the force of a contraction, and then measures it again at a longer length, the force is found to be higher. If by making other interventions, such as increasing the calcium ion (Ca2+) concentration of the extracellular fluid, and the… View more