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Author(s): Juan Tamargo Added: 3 years ago
Chronic heart failure (HF) is a complex and progressive clinical syndrome resulting from any abnormality of cardiac structure or function. The American College of Cardiology Foundation/American Heart Association guideline defines HF as ‘a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood’.1 The European Society of… View more

Heart Failure
Author(s): Sam Hayman , John J Atherton Added: 3 years ago
Heart failure (HF) is associated with significant morbidity and mortality and confers a major economic burden.1 Large randomised controlled trials (RCTs) have demonstrated that inhibition of the renin–angiotensin– aldosterone and sympathetic nervous systems improve outcomes in patients with HF and a reduced left ventricular ejection fraction (HFrEF) (see Figure 1),2–9 with clinical guidelines… View more

Heart Failure
Current Understanding of the Compensatory Actions of Cardiac Natriuretic Peptides in Cardiac Failure: A Clinical Perspective
Author(s): Noel S Lee , Lori B Daniels Added: 3 years ago
Today, natriuretic peptides are ubiquitously utilized for the diagnosis, treatment, and prognostication of heart failure in the Emergency Department, as well as inpatient and outpatient settings alike.1–5 These endogenous hormones counteract some of the most detrimental effects of heart failure. Given their clinical and physiological importance, the fact that a manuscript describing the… View more

Heart Failure

Prevention & Chronic Conditions
Foreword

Article

Author(s): Andrew JS Coats , Giuseppe Rosano Added: 3 years ago
We have great pleasure in introducing the second volume of Cardiac Failure Review to our readers. In recent weeks we have attended innovative conferences that have highlighted new devices that show great promise in heart failure treatment, one in Brussels, Belgium that coincided with the tragic events there, and one in Seoul, Korea – an impressive emerging Asian superstar. In heart failure news,… View more

Heart Failure
Sacubitril/Valsartan: Milestone in HFrEF Treatment
Author(s): Mauro Gori , James L Januzzi , Emilia D’Elia , et al Added: 3 years ago

Heart Failure
Author(s): Thomas G von Lueder , Dipak Kotecha , Dan Atar , et al Added: 3 years ago
Heart Failure (HF) constitutes a major global health problem, evidenced by substantial morbidity and mortality, requiring enormous healthcare-related expenditure. HF is associated with high symptomatic burden, and with a relentless and progressive clinical course towards end-stage disease. A large body of epidemiological data suggests that the prognosis in HF is as poor as in advanced cancer.1… View more

Heart Failure
Author(s): Bao Tran , Gregg C Fonarow Added: 3 years ago
Heart failure (HF) remains a major public health problem resulting in substantial morbidity, mortality and healthcare expenditures globally. The European Society of Cardiology (ESC) 2012 Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure and the American College of Cardiology Foundation (ACCF)/American Heart Association (AHA) 2013 Guideline for the Management of Heart… View more

Standards & Guidelines

Heart Failure
Suppression of Tumourigenicity 2 in Heart Failure With Preserved Ejection Fraction
Author(s): Veronika Zach , Felix Lucas Bähr , Frank Edelmann Added: 4 years ago
Heart failure (HF) is a chronic, progressive disease with steadily increasing incidence rates and high morbidity and mortality that represents a major challenge in healthcare worldwide.1–3 The disease is characterised by chronic exacerbations, recurrent hospitalisations and poor prognosis.1,2 Survival rates in HF patients are lower than in patients suffering from some malignant diseases,… View more

Heart Failure

Electrophysiology & Arrhythmia
Neprilysin as a Biomarker: Challenges and Opportunities
Author(s): Noemi Pavo , Suriya Prausmüller , Philipp E Bartko , et al Added: 3 years ago
Neprilysin (NEP) was more or less unrecognised by the cardiovascular community until 2014 when the Prospective Comparison of ARNi With ACEi to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study reported impressive clinical benefits resulting from the combination of an angiotensin receptor blocker (ARB) with a neprilysin inhibitor (angiotensin receptor… View more

MI/ACS
Author(s): Frans H Rutten , Joe Gallagher Added: 3 years ago
“I cannot keep pace with my husband. Is it simply ageing, overweight and my sedentary lifestyle?” This is a common encounter in primary care, bearing in mind that around 16 % of older community-dwelling people experience at least grade 3 shortness of breath according to the Medical Research Council questionnaire (“walk slower than people of the same age because of breathlessness or have to stop… View more

Standards & Guidelines

Heart Failure