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Mechanisms of Myocardial Injury in Coronavirus Disease 2019
Author(s): Aniket S Rali , Sagar Ranka , Zubair Shah , et al Added: 3 years ago
Coronavirus disease 2019 (COVID-19) has evolved into a global pandemic, having affected more than 2.3 million people and claiming more than 160,000 lives. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus predominantly causes fever (77–98% of cases), fatigue (52–75%) and cough (60–81%).1,2 While it primarily affects the respiratory system, it also appears to… View more

COVID-19
EASD 23: Efinopegdutide in NAFLD & T2D patients
Author(s): Samuel S Engel Added: 6 months ago
EASD 2023 — In this short interview, Dr Samuel S Engel (Associate Vice President at Merck) discusses a study investigating the effectiveness and safety of efinopegdutide (MK-6024) in patients with nonalcoholic fatty liver disease and type 2 diabetes (NCT04944992).The phase IIa study randomized 145 participants (efinopegdutide, n = 72; semaglutide, n = 73). The majority (55.2%) of participants… View more

Prevention & Chronic Conditions
Author(s): Juan Tamargo Added: 3 years ago
Chronic heart failure (HF) is a complex and progressive clinical syndrome resulting from any abnormality of cardiac structure or function. The American College of Cardiology Foundation/American Heart Association guideline defines HF as ‘a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood’.1 The European Society of… View more

Heart Failure
Author(s): Thomas G von Lueder , Dipak Kotecha , Dan Atar , et al Added: 3 years ago
Heart Failure (HF) constitutes a major global health problem, evidenced by substantial morbidity and mortality, requiring enormous healthcare-related expenditure. HF is associated with high symptomatic burden, and with a relentless and progressive clinical course towards end-stage disease. A large body of epidemiological data suggests that the prognosis in HF is as poor as in advanced cancer.1… View more

Heart Failure
Foreword

Article

Author(s): Andrew JS Coats , Giuseppe Rosano Added: 3 years ago
We have great pleasure in introducing the second volume of Cardiac Failure Review to our readers. In recent weeks we have attended innovative conferences that have highlighted new devices that show great promise in heart failure treatment, one in Brussels, Belgium that coincided with the tragic events there, and one in Seoul, Korea – an impressive emerging Asian superstar. In heart failure news,… View more

Heart Failure
Subclinical Left Ventricular Dysfunction During Chemotherapy
Author(s): Martin Nicol , Mathilde Baudet , Alain Cohen-Solal Added: 3 years ago
Advances in the early detection and treatment of cancer have improved overall survival in cancer patients. Nevertheless, cardiovascular diseases appear as the major cause of morbidity and mortality among cancer survivors.1 Left ventricular (LV) dysfunction and/or heart failure are the most common cardiovascular complications after administration of chemotherapies. The term ‘cardiotoxicity’ is… View more

Heart Failure

CV Disease in Special Populations
Fluid Management in Patients with Chronic Heart Failure
Author(s): Pierpaolo Pellicori , Kuldeep Kaur , Andrew L Clark Added: 3 years ago
Heart failure (HF) is one of the most common reasons for admission to hospital. It is associated with long in-patient stays, and has a high in-hospital and post-discharge morbidity and mortality, whether left ventricular ejection fraction (LVEF) is reduced (HFREF) or normal (HeFNEF).1,2 Congestion, or fluid overload, is a classic clinical feature of patients presenting with HF. In some patients,… View more

Heart Failure

Prevention & Chronic Conditions
Inotropes in Acute Heart Failure: From Guidelines to Practical Use: Therapeutic Options and Clinical Practice
Author(s): Vasiliki Bistola , Angelos Arfaras-Melainis , Eftihia Polyzogopoulou , et al Added: 3 years ago
Acute heart failure (AHF) is defined as the sudden presentation or sudden aggravation of signs and symptoms of heart failure, often requiring hospitalisation.1 It is a life-threatening condition, with in-hospital mortality ranging from 22% to 37% in severe cases of cardiogenic shock.2–4 Inotropes have been used in the management of patients with AHF for decades, especially for patients with… View more

Heart Failure
Author(s): Sam Hayman , John J Atherton Added: 3 years ago
Heart failure (HF) is associated with significant morbidity and mortality and confers a major economic burden.1 Large randomised controlled trials (RCTs) have demonstrated that inhibition of the renin–angiotensin– aldosterone and sympathetic nervous systems improve outcomes in patients with HF and a reduced left ventricular ejection fraction (HFrEF) (see Figure 1),2–9 with clinical guidelines… View more

Heart Failure
Morphine in the Setting of Acute Heart Failure: Do the Risks Outweigh the Benefits?
Author(s): Oren Caspi , Doron Aronson Added: 3 years ago
Heart failure is a growing pandemic worldwide, and it is associated with a high burden of morbidity and mortality. Acute heart failure (AHF) is one of the most prevalent causes of adult patients’ hospitalisation. While the treatment of most cardiovascular diseases has significantly improved since the beginning of this century, the outcomes of AHF have not progressed significantly, and AHF still… View more

Heart Failure